|
CYP1A2 inducers
|
|
omeprazole
|
|
phenobarbital, phenytoin (moderate)
|
|
rifampicin (moderate), ritonavir (moderate)
|
|
tobacco smoking
|
|
CYP1A2 inhibitors
|
|
cannabidiol, ciprofloxacin (strong), combined oral contraceptives (moderate)
|
|
fluvoxamine (strong)
|
|
peginterferon alfa-2a
|
|
vemurafenib, verapamil
|
|
CYP1A2 substrates
|
|
agomelatine, amitriptyline, asenapine, axitinib
|
|
bendamustine
|
|
caffeine, clozapine
|
|
duloxetine
|
|
erlotinib
|
|
fluvoxamine
|
|
imipramine
|
|
lidocaine
|
|
olanzapine, ondansetron
|
|
paracetamol, pirfenidone, pomalidomide, propranolol
|
|
rasagiline, ropinirole, ropivacaine
|
|
stiripentol
|
|
theophylline
|
|
warfarin (R-isomer)
|
|
zolmitriptan
|
|
CYP2B6 inducers
|
|
carbamazepine (strong)
|
|
efavirenz (moderate)
|
|
isavuconazole
|
|
midostaurin
|
|
nevirapine
|
|
phenobarbital, phenytoin
|
|
rifampicin (moderate), ritonavir (moderate)
|
|
CYP2B6 inhibitors
|
|
clopidogrel
|
|
prasugrel
|
|
voriconazole
|
|
CYP2B6 substrates
|
|
bupropion
|
|
clopidogrel, cyclophosphamide
|
|
efavirenz
|
|
ifosfamide
|
|
methadone
|
|
nevirapine
|
|
velpatasvir
|
|
CYP2C8 inducers
|
|
rifampicin (moderate)
|
|
CYP2C8 inhibitors
|
|
clopidogrel (strong)
|
|
gemfibrozil (strong)
|
|
trimethoprim
|
|
CYP2C8 substrates
|
|
apalutamide
|
|
dabrafenib
|
|
enzalutamide, etrasimod
|
|
ozanimod (metabolite)
|
|
paclitaxel, pioglitazone
|
|
selexipag
|
|
velpatasvir
|
|
CYP2C9 inducers
|
|
apalutamide, aprepitant (moderate)
|
|
bosentan
|
|
carbamazepine (moderate)
|
|
dabrafenib
|
|
enzalutamide (moderate)
|
|
rifampicin (moderate), ritonavir (moderate)
|
|
St John's wort
|
|
CYP2C9 inhibitors
|
|
amiodarone (moderate), asciminib
|
|
benzbromarone (moderate)
|
|
ceritinib
|
|
efavirenz, etravirine
|
|
fluconazole (moderate), fluoxetine, fluvoxamine
|
|
miconazole
|
|
ritonavir
|
|
voriconazole
|
|
CYP2C9 substrates
|
|
amitriptyline, avatrombopag
|
|
bosentan
|
|
celecoxib, cyclophosphamide
|
|
etrasimod, etravirine
|
|
fluoxetine, fluvastatin
|
|
glibenclamide, gliclazide, glimepiride, glipizide
|
|
ibuprofen
|
|
phenytoin
|
|
rosuvastatin, ruxolitinib
|
|
siponimod
|
|
tamoxifen
|
|
voriconazole
|
|
warfarin (S-isomer)
|
|
CYP2C19 inducers
|
|
apalutamide (strong)
|
|
efavirenz (moderate), enzalutamide (moderate)
|
|
rifampicin (strong), ritonavir (strong)
|
|
St John's wort
|
|
CYP2C19 inhibitors
|
|
clarithromycin
|
|
efavirenz, esomeprazole, etravirine
|
|
fluconazole (strong), fluoxetine (strong), fluvoxamine (strong)
|
|
ketoconazole
|
|
omeprazole, oxcarbazepine
|
|
stiripentol
|
|
topiramate
|
|
voriconazole (moderate)
|
|
CYP2C19 substrates
|
|
amitriptyline, axitinib
|
|
bortezomib, brivaracetam
|
|
cannabidiol, citalopram, clopidogrel, cyclophosphamide
|
|
diazepam
|
|
escitalopram, esomeprazole, etravirine
|
|
imipramine
|
|
lansoprazole
|
|
mavacamten
|
|
omeprazole
|
|
pantoprazole, phenobarbital, phenytoin, propranolol
|
|
stiripentol
|
|
voriconazole
|
|
warfarin (R-isomer)
|
|
CYP2D6 inhibitors
|
|
abiraterone, amiodarone
|
|
bupropion (strong)
|
|
celecoxib, cinacalcet (moderate), cobicistat
|
|
duloxetine (moderate)
|
|
fluoxetine (strong)
|
|
methadone, mirabegron (moderate)
|
|
paroxetine (strong)
|
|
terbinafine (strong)
|
|
CYP2D6 substrates
|
|
amitriptyline, aripiprazole, atomoxetine
|
|
bortezomib, brexpiprazole
|
|
carvedilol, chlorpromazine, cinacalcet, clozapine, codeine
|
|
dapoxetine, darifenacin, dextromethorphan, donepezil, duloxetine
|
|
flecainide, fluoxetine, fluvoxamine
|
|
galantamine, gefitinib
|
|
haloperidol
|
|
imipramine
|
|
lidocaine
|
|
metoclopramide, metoprolol
|
|
nebivolol, nortriptyline
|
|
olanzapine, ondansetron, oxycodone
|
|
paroxetine, perhexiline, propranolol
|
|
risperidone
|
|
tamoxifen, tolterodine, tramadol
|
|
venlafaxine, vortioxetine
|
|
CYP3A4/5 inducers
|
|
apalutamide (strong), aprepitant, armodafinil
|
|
bosentan (moderate), brigatinib
|
|
carbamazepine (strong), corticosteroids
|
|
dabrafenib
|
|
efavirenz (moderate), encorafenib (strong), enzalutamide (strong), etravirine (moderate)
|
|
lorlatinib (moderate), lumacaftor (strong)
|
|
modafinil (moderate)
|
|
nevirapine
|
|
phenobarbital, phenytoin (strong)
|
|
rifabutin, rifampicin (strong), ritonavir, rufinamide
|
|
St John's wort (strong)
|
|
vemurafenib
|
|
CYP3A4/5 inhibitors
|
|
amiodarone, aprepitant (moderate), asciminib, atazanavir (moderate), avacopan
|
|
ceritinib (strong), ciclosporin (moderate), clarithromycin (strong), cobicistat (strong), crizotinib (moderate)
|
|
darunavir, diltiazem (moderate)
|
|
encorafenib, erythromycin (moderate)
|
|
fluconazole (moderate), fluvoxamine (moderate)
|
|
grapefruit juice (moderate)
|
|
idelalisib (strong), imatinib (moderate), isavuconazole (moderate), itraconazole (strong)
|
|
ketoconazole (strong)
|
|
larotrectinib, lenacapavir (moderate), letermovir (moderate), lopinavir
|
|
maribavir, miconazole
|
|
netupitant
|
|
palbociclib, posaconazole (strong)
|
|
ribociclib, ritonavir (strong)
|
|
stiripentol
|
|
ticagrelor
|
|
verapamil (moderate), voriconazole (strong)
|
|
CYP3A4/5 substrates
|
|
abemaciclib, abiraterone, acalabrutinib, alfentanil, alprazolam, amiodarone, amitriptyline, apalutamide, apixaban, apremilast, aprepitant, aripiprazole, asciminib, atazanavir, atorvastatin, avacopan, avanafil, avatrombopag, axitinib
|
|
betamethasone, bictegravir, bortezomib, bosentan, brentuximab vedotin, brexpiprazole, brigatinib, buspirone, budesonide, busulfan
|
|
cabazitaxel, cabozantinib, cannabidiol, carbamazepine, cariprazine, ceritinib, ciclosporin, cinacalcet, cisapride, clarithromycin, clopidogrel, cobicistat, cobimetinib, cocaine, codeine, colchicine, crizotinib, cyclophosphamide
|
|
dabrafenib, dapoxetine, darifenacin, darolutamide, darunavir, dasatinib, dexamethasone, diazepam, diltiazem, disopyramide, docetaxel, domperidone, donepezil
|
|
eletriptan, elexacaftor, elvitegravir, encorafenib, enfortumab vedotin, entrectinib, enzalutamide, eplerenone, ergometrine, erlotinib, erythromycin, esomeprazole, ethinylestradiol, etonogestrel, etoposide, etoricoxib, etrasimod, etravirine, everolimus
|
|
felodipine, fentanyl, finerenone, fluticasone, fluvastatin, fostemsavir
|
|
galantamine, gefitinib, gilteritinib, guanfacine
|
|
haloperidol, hydrocortisone
|
|
ibrutinib, idelalisib, ifosfamide, imatinib, imipramine, irinotecan, isavuconazole, itraconazole, ivabradine, ivacaftor
|
|
ketoconazole
|
|
lapatinib, larotrectinib, lemborexant, lenacapavir, lercanidipine, levonorgestrel, lidocaine, lopinavir, lorlatinib, lurasidone
|
|
macitentan, maraviroc, maribavir, mavacamten, methylprednisolone, midazolam, midostaurin, mifepristone, mirabegron, mirtazapine
|
|
netupitant, nevirapine, nifedipine, nilotinib, nimodipine, nirmatrelvir, norethisterone
|
|
olaparib, omeprazole, ondansetron, osimertinib, oxycodone
|
|
paclitaxel, palbociclib, perampanel, pazopanib, pomalidomide, ponatinib, propranolol
|
|
quetiapine, quinine
|
|
reboxetine, regorafenib, ribociclib, rifabutin, rilpivirine, ripretinib, risperidone, ritonavir, rivaroxaban, romidepsin, ruxolitinib
|
|
salmeterol, sildenafil, silodosin, simvastatin, siponimod, sirolimus, solifenacin, sonidegib, sorafenib, stiripentol, sunitinib, suvorexant
|
|
tacrolimus, tadalafil, tamoxifen, tezacaftor, tiagabine, ticagrelor, tofacitinib, tolterodine, tolvaptan, toremifene, trabectedin, tramadol, triamcinolone
|
|
ulipristal, upadacitinib
|
|
vandetanib, velpatasvir, vemurafenib, venetoclax, venlafaxine, verapamil, vinblastine, vincristine, vinorelbine, voriconazole, voxilaprevir
|
|
warfarin (R-isomer)
|
|
zanubrutinib, ziprasidone, zolpidem
|
